A COVID-19 vaccine is administered in Toronto on Monday, Dec. 14, 2020. THE CANADIAN PRESS/Frank Gunn

A COVID-19 vaccine is administered in Toronto on Monday, Dec. 14, 2020. THE CANADIAN PRESS/Frank Gunn

Clinical trials start for Canadian COVID-19 vaccine candidate

Dubbed COVAC-2, the vaccine hopeful was developed by the Vaccine and Infectious Disease Organization

Clinical trials have begun for another Canadian-made COVID-19 vaccine candidate, with three people receiving an initial dose on Wednesday.

The Canadian Center for Vaccinology says the first of 108 healthy adult volunteers received injections in Halifax. The placebo-controlled study will administer two doses to each volunteer, 28 days apart.

“It’s a product of Canadian science, so it bodes well for the ability to make vaccines here. We all want to have vaccine manufacturing capacity in Canada,” said Dr. Joanne Langley, a vaccine researcher with the centre.

She said that the pace of testing is careful, as different age groups, from younger to older, receive varying doses in a process that will unfold over the next two months.

Dubbed COVAC-2, the vaccine hopeful was developed by the Vaccine and Infectious Disease Organization, or VIDO, at the University of Saskatchewan in Saskatoon.

It’s the first of two subunit vaccines by VIDO to enter clinical testing. Subunit vaccines contain purified viral proteins that are not infectious, and employ technology already used in vaccines for hepatitis, diphtheria, and whooping cough.

Darryl Falzarano, a vaccine researcher at VIDO, said he’s hoping that his institute’s promising tests on ferrets and hamsters will translate into safe and effective results in the human testing phase.

“Safety is the primary indicator (in the first phase) but you will also be looking at immune response,” he said.

Langley said the testing in the first phase is to determine safety to humans, and the participants will keep a diary that measure any pain or redness of the arm. The trial will also measure antibody responses, she said.

The next step would be to do trials at multiple sites around the country.

It is only in Phase 3 that the vaccine is compared against a placebo or another vaccine to see how well it protects against COVID-19, said Langley.

She said the entire vaccine testing process, if all went well, could take about nine months, adding that is a “very wishful, optimistic scenario.”

VIDO has said in a news release the product doesn’t need ultra-cold storage temperatures like synthetic messenger RNA or mRNA products. The two Health Canada-approved vaccines by Moderna and Pfizer-BioNTech each require special distribution and storage procedures that have complicated their rollout.

It follows the launch last month of clinical trials for a prospective vaccine by Calgary’s Providence Therapeutics, and last year’s launch of trials for a vaccine hopeful by Quebec City’s Medicago.

VIDO’s vaccine antigen – a molecule that triggers an immune response – was produced at Quebec-based Biodextris using a cell line from the National Research Council of Canada.

Development help also came from partners around the world, including Seppic in France and the Vaccine Formulation Institute in Switzerland.

At the same time, VIDO is building a manufacturing facility on the USask campus that could produce up to 40 million vaccine doses, but it wasn’t certain if that would include VIDO’s product. Construction is expected to be completed late this year.

Falzarano said the team in Saskatoon is excited the process is beginning, as this form of vaccine can be mass produced at a rapid rate if successful.

“It’s only the beginning of a multi-step process, but at least we’ve gotten to this milestone,” he said.

ALSO READ: Experts say race for COVID drugs dogged by false promises, lack of co-ordination

Michael Tutton and Cassandra Szklarski, The Canadian Press


Like us on Facebook and follow us on Twitter.

Want to support local journalism during the pandemic? Make a donation here.

Coronavirusvaccines

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

Pitt Meadows United Church has a new Expression Station, to create a record of people’s feelings during this stage of the COVID-19 pandemic. (Special to The News)
Closed by COVID-19, Pitt Meadows church offers Expression Station

Say what you need to say in this pandemic time, offers United Church

Police tape is shown in Toronto Tuesday, May 2, 2017. (Graeme Roy/The Canadian Press)
CRIME STOPPERS: ‘Most wanted’ for the week of Feb. 28

Crime Stoppers’ weekly list based on information provided by police investigators

On Monday, March 1, 2021, Maple Ridge is hosting an information session on Choose to Move, a fitness program for people 65 and older. (Maple Ridge image)
Maple Ridge seniors invited to information session on free fitness program

Learn about the program for those 65 and older on Monday, March 1

Phyllis Neufeld was on the Alouette River dike in Pitt Meadows on Wednesday, Feb. 17, 2021, when she took this photo. (Special to The News)
SHARE: Sun breaks through a rainy Pitt Meadows sky

Send us your photo showing how you view Maple Ridge or Pitt Meadows, and it could be featured soon.

The artwork is by Caitlin Legault who is not the only local person grateful to those who work in health care. A local letter writer recently had to go to hospital and wanted everyone there to know that their efforts are appreciated. (Special to The News)
LETTER: Pitt Meadows letter writer grateful for all those who cared for her at hospital

Staff in every department worthy of praise, local woman says

A health worker holds a vial of AstraZeneca vaccine to be administered to members of the police at a COVID-19 vaccination center in Mainz, Germany, Thursday, Feb. 25, 2021. The federal state of Rhineland-Palatinate, start with the vaccination of police officers in internal police vaccination centers. (Andreas Arnold/dpa via AP)
B.C. officials to unveil new details of COVID vaccination plan Monday

Seniors and health-care workers who haven’t gotten their shot are next on the list

An investigation is underway after a man was shot and killed by Tofino RCMP in Opitsaht. (Black Press Media file photo)
Man shot and killed by RCMP near Tofino, police watchdog investigating

Investigation underway by Independent Investigations Office of British Columbia.

B.C. Supreme Court in Vancouver on Tuesday December 11, 2018. THE CANADIAN PRESS/Darryl Dyck
B.C.’s compromise on in-person worship at three churches called ‘absolutely unacceptable’

Would allow outdoor services of 25 or less by Langley, Abbotsford and Chilliwack churches

Baldy Mountain Resort was shut down on Saturday after a fatal workplace accident. (Baldy Mountain picture)
Cannabis bought in British Columbia (Ashley Wadhwani/Black Press Media)
Is it time to start thinking about greener ways to package cannabis?

Packaging suppliers are still figuring eco-friendly and affordable packaging options that fit the mandates of Cannabis Regulations

Alina Durham, mother of Shaelene Bell, lights candles on behalf of Bell’s two sons during a vigil on Saturday, Feb. 27, 2021. (Jenna Hauck/ Chilliwack Progress)
VIDEO and PHOTOS: Candlelight vigil for missing Chilliwack woman sends message of hope

Small group of family, friends gathered to shine light for 23-year-old mother Shaelene Bell

Jasmine and Gwen Donaldson are part of the CAT team working to reduce stigma for marginalized groups in Campbell River. Photo by Marc Kitteringham, Campbell River Mirror
Jasmine’s story: Stigma can be the hardest hurdle for those overcoming addiction

Recovering B.C. addict says welcome, connection and community key for rebuilding after drug habit

A Vancouver restaurant owner was found guilty of violating B.C.’s Human Rights Code by discriminating against customers on the basis of their race. (Pixabay)
Vancouver restaurant owner ordered to pay $4,000 to customers after racist remark

Referring to patrons as ‘you Arabs’ constitutes discrimination under B.C.’s Human Rights Code, ruling deems

Approximate location of the vehicle incident. (Google Maps)
Vehicle incident blocking Coquihalla traffic in both directions

Both directions of traffic stopped due to vehicle incident

Most Read